Exciting Clinical Trials and Breakthroughs in 2023

Introduction:


Medicine is evolving n a daily basis, new trials, and new major breakthroughs are made, making the future of healthcare look bright. in 2023 we can see that many trials are being pushed in, especially in Cancer treatment and neurodegenerative diseases, we will try to talk about some of the most anticipated clinical trials and their huge impact on medicine.

Exenatide: which is a diabetes treatment, can it be used to treat Parkinson disease?:

The clinical trials are currently at the phase 3 and the results are indeed coming out soon, it has shown some promising preclinical results and phase 2 results on how Exenatide which is basically a diabetes Type 2 treatment that inhibits glucagon secretion in the treatment of Parkinson disease. it is offering hope to reuse a drug that can be ready to be used in clinical Practice [1].


Mirvetuximab Soravtansine: Advancing Ovarian Cancer Treatment:

This drug is a revolution in terms of Ovarian Cancer treatment, therefor it received accelerated approval from the US Food and Drug Administration (FDA) on November 2022. it is under going trial in order to prove its effectiveness to treat platinum-resistant ovarian cancer. if all goes well in the trials and it comes out as a success it will provide for the patients an additional option especialy in the recurrent cases of ovarian cancer [1].

Polygenic Scores for Enhanced Prostate Cancer Screening:

The clinicians usual use of PSA (Prostate-specific antigen) Screening to detect prostate cancer just got improved, and that by sensibilizing the test accuracy and taking into consideration the polygenic scores. that will make the PSA screening test enhanced, and individualized accordingly to their genetic variability [2].

Integrated Multi-Omics for Rare Disease Diagnosis:

a Demonstration has been made by the Australian Acute Care Genomics program and that of integrationg rapid whole-genome sequencing and Multi-omic analyses in order to diagnose rare diseases, the study was a perspective cohort in the case of a fatally ill children and new born, this new technique helped the diagnoses and to decide on which treatment to under go. rare disease can be diagnosed accuratly and rapidly using the comprehensive genomic and multi omic data, especially in disease which intervention at a precose period makes a huge different in the prognosis of patients and their future [2].

MESOTHELIOMA Clinical Trials :
There are countless of studies and trials under going in the case of MESOTHELIOMA we can talk about ADI-PEG 20 (pegylated arginine deiminase), the Mesothelioma malignant cells have been proved to require Arginine which is an aminoacid, and using ADI-PEG 20 will deprive the cells and starve them to death [3].
You can find other studies on the matter of Mesothelioma Clinical Trials here :
Mesothelioma Clinical Trials

References:

1- 11 clinical trials that will shape medicine in 2023 – Nature
2- Articles in 2023 | Nature Medicine
3- A Study in Subjects with Malignant Pleural Mesothelioma to Assess ADI-PEG 20 with Pemetrexed and Cisplatin